Article
A canonical structure for the ligand-binding domain of nuclear receptors.
Nature structural biology - 1 Jan 1996
Wurtz J M, Bourguet W, Renaud J P, Vivat V, Chambon P, Moras D, Gronemeyer H
Abstract excerpt
The ability of nuclear receptors (NRs) to activate transcription of target genes requires the binding of cognate ligands to their ligand-binding domains (LBDs). Information provided by the three-dimensional structures of the unliganded RXR alpha and the liganded RAR gamma LBDs has been incorporat...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Humans
- Ligands
- Molecular Sequence Data
- Mutation
- Protein Folding
- Receptors, Cytoplasmic and Nuclear
- Sequence Alignment