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Article

A canonical structure for the ligand-binding domain of nuclear receptors.

Nature structural biology - 1 Jan 1996

Wurtz J M, Bourguet W, Renaud J P, Vivat V, Chambon P, Moras D, Gronemeyer H

Abstract excerpt

The ability of nuclear receptors (NRs) to activate transcription of target genes requires the binding of cognate ligands to their ligand-binding domains (LBDs). Information provided by the three-dimensional structures of the unliganded RXR alpha and the liganded RAR gamma LBDs has been incorporated into a general alignment of the LBDs of all NRs. A twenty amino-acid region constitutes a NR-specific signature and...

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Identifiers

PMID: 8548460
DOI: 10.1038/nsb0196-87

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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