Natural disordered sequences in the amino terminal domain of nuclear receptors: lessons from the androgen and glucocorticoid receptors.

Abstract excerpt

Steroid hormones are a diverse class of structurally related molecules, derived from cholesterol, that include androgens, estrogens, progesterone and corticosteroids. They represent an important group of physiologically active signalling molecules that bind intracellular receptor proteins and regulate genes involved in developmental, reproductive and metabolic processes. The receptor proteins share structurally...

Topics

• Amino Acid Sequence
• Computer Simulation
• Hartnup Disease
• Models, Chemical
• Models, Molecular
• Molecular Sequence Data
• Mutation
• Protein Structure, Tertiary
• Receptors, Androgen
• Receptors, Glucocorticoid
• Sequence Analysis, Protein