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Article

Functional constraints on the constitutive androstane receptor inferred from human sequence variation and cross-species comparisons.

Human genomics - 1 Sept 2005

Thompson Emma E, Kuttab-Boulos Hala, Krasowski Matthew D, Di Rienzo Anna

Abstract excerpt

Members of the NR1I subfamily of nuclear receptors play a role in the transcriptional activation of genes involved in drug metabolism and transport. NR1I3, the constitutive androstane receptor (CAR), mediates the induction of several genes involved in drug response, including members of the CYP3A, CYP2B and UGT1A subfamilies. Large inter-individual variation in drug clearance has been reported for many drug...

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Identifiers

PMID: 16197734
DOI: 10.1186/1479-7364-2-3-168
PMCID: PMC3525124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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