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Article

Molecular dynamics simulations of the human CAR ligand-binding domain: deciphering the molecular basis for constitutive activity.

Journal of molecular modeling - 1 Feb 2005

Windshügel Björn, Jyrkkärinne Johanna, Poso Antti, Honkakoski Paavo, Sippl Wolfgang

Abstract excerpt

The constitutive androstane receptor (CAR) belongs to the superfamily of nuclear-hormone receptors that function as ligand-activated transcription factors. CAR plays an essential role in the metabolism of xenobiotics and shows--in contrast to related receptors--constitutive activity. However, the molecular basis for the constitutive activity remains unclear. In the present study, homology models of the ligand...

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Source

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PMID: 15616833
DOI: 10.1007/s00894-004-0227-4

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VDR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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