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Article

Alternatively spliced isoforms of the human constitutive androstane receptor

10 Jun 2003

Abstract excerpt

The nuclear receptor CAR (NR1I3) regulates transcription of genes encoding xenobiotic- and steroid-metabolizing enzymes. Regulatory processes that are mediated by CAR are modulated by a structurally diverse array of chemicals including common pharmaceutical and environmental agents. Here we describe four in-frame splice variants of the human CAR receptor gene. The variant mRNA splice transcripts were expressed in...

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PMID: 12799447
DOI: 10.1093/nar/gkg419

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