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Article

Analysis of the LKB1-STRAD-MO25 complex

24 Nov 2004

Abstract excerpt

Mutations in the LKB1 tumour suppressor threonine kinase cause the inherited Peutz-Jeghers cancer syndrome and are also observed in some sporadic cancers. Recent work indicates that LKB1 exerts effects on metabolism, polarity and proliferation by phosphorylating and activating protein kinases belonging to the AMPK subfamily. In vivo, LKB1 forms a complex with STRAD, an inactive pseudokinase, and MO25, an...

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Identifiers

PMID: 15561763
DOI: 10.1242/jcs.01571

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Analysis of the LKB1-STRAD-MO25 complexPMID 15561763Read ↗

Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation.Semantic proximity Read ↗

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Controlling the master-upstream regulation of the tumor suppressor LKB1.Semantic proximity Read ↗

Insights into targeting LKB1 in tumorigenesisSemantic proximity Read ↗

The role of STK11/LKB1 in cancer biology: implications for ovarian tumorigenesis and progressionSemantic proximity Read ↗

Molecular insights and therapeutic implications for the tumor suppressor role of LKB1 in non-small cell lung cancer.Semantic proximity Read ↗

Structure of the MST4 in complex with MO25 provides insights into its activation mechanism.Semantic proximity Read ↗

The molecular mechanisms that underlie the tumor suppressor function of LKB1.Semantic proximity Read ↗

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