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Article

Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation.

Science (New York, N.Y.) - 18 Dec 2009

Zeqiraj Elton, Filippi Beatrice Maria, Deak Maria, Alessi Dario R, van Aalten Daan M F

Abstract excerpt

The LKB1 tumor suppressor is a protein kinase that controls the activity of adenosine monophosphate-activated protein kinase (AMPK). LKB1 activity is regulated by the pseudokinase STRADalpha and the scaffolding protein MO25alpha through an unknown, phosphorylation-independent, mechanism. We describe the structure of the core heterotrimeric LKB1-STRADalpha-MO25alpha complex, revealing an unusual allosteric...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19892943
DOI: 10.1126/science.1178377
PMCID: PMC3518268

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation.PMID 19892943Read ↗

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