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Article

ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor.

PLoS biology - 9 Jun 2009

Zeqiraj Elton, Filippi Beatrice Maria, Goldie Simon, Navratilova Iva, Boudeau Jérôme, Deak Maria, Alessi Dario R, van Aalten Daan M F

Abstract excerpt

Pseudokinases lack essential residues for kinase activity, yet are emerging as important regulators of signal transduction networks. The pseudokinase STRAD activates the LKB1 tumour suppressor by forming a heterotrimeric complex with LKB1 and the scaffolding protein MO25. Here, we describe the structure of STRADalpha in complex with MO25alpha. The structure reveals an intricate web of interactions between...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19513107
DOI: 10.1371/journal.pbio.1000126
PMCID: PMC2686265

Genes

CDK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor.PMID 19513107Read ↗

Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation.Semantic proximity Read ↗

Analysis of the LKB1-STRAD-MO25 complexSemantic proximity Read ↗

Emerging roles of pseudokinases.Semantic proximity Read ↗

Small molecule activation of the tumor suppressor kinase LKB1Semantic proximity Read ↗

Structural insights into the activation of MST3 by MO25.Semantic proximity Read ↗

Mitogen-activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment.Semantic proximity Read ↗

LKB1-dependent signaling pathways.Semantic proximity Read ↗

B56δ long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations.Semantic proximity Read ↗

Regulation of AMP-activated protein kinase by a pseudosubstrate sequence on the gamma subunit.Semantic proximity Read ↗

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.Semantic proximity Read ↗

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