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Article

Structural insights into the activation of MST3 by MO25.

Biochemical and biophysical research communications - 15 Feb 2013

Mehellou Youcef, Alessi Dario R, Macartney Thomas J, Szklarz Marta, Knapp Stefan, Elkins Jonathan M

Abstract excerpt

The MO25 scaffolding protein operates as critical regulator of a number of STE20 family protein kinases (e.g. MST and SPAK isoforms) as well as pseudokinases (e.g. STRAD isoforms that play a critical role in activating the LKB1 tumour suppressor). To better understand how MO25 interacts and stimulates the activity of STE20 protein kinases, we determined the crystal structure of MST3 catalytic domain (residues...

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Identifiers

PMID: 23296203
DOI: 10.1016/j.bbrc.2012.12.113
PMCID: PMC3725419

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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