Article

Small molecule activation of the tumor suppressor kinase LKB1

2024-12-20

Abstract excerpt

The ability to identify and target oncogenic signals has transformed clinical oncology. Drug development for targeted therapies has historically focused on the inhibition of oncogenic kinases and GTPases. However, many cancer patients do not benefit from targeted approaches because their tumors lack targetable mutations. Therapeutic augmentation of tumor suppressive signaling could be a viable alternative but pose...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 574d9352-6ebd-5b02-8fdc-c69f8b56629c
DOI: 10.1101/2024.12.17.628051

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Small molecule activation of the tumor suppressor kinase LKB1DOI 10.1101/2024.12.17.628051Read

Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation.Semantic proximity Read

Insights into targeting LKB1 in tumorigenesisSemantic proximity Read

Analysis of the LKB1-STRAD-MO25 complexSemantic proximity Read

LKB1-dependent signaling pathways.Semantic proximity Read

Structural insights into the activation of MST3 by MO25.Semantic proximity Read

Targeting LKB1 in cancer - exposing and exploiting vulnerabilities.Semantic proximity Read

Recent advances in targeting protein kinases and pseudokinases in cancer biologySemantic proximity Read

Molecular insights and therapeutic implications for the tumor suppressor role of LKB1 in non-small cell lung cancer.Semantic proximity Read

Targeting the LKB1 tumor suppressor.Semantic proximity Read

The role of STK11/LKB1 in cancer biology: implications for ovarian tumorigenesis and progressionSemantic proximity Read

Emerging roles of pseudokinases.Semantic proximity Read

Targeting LKB1 signaling in cancerSemantic proximity Read