Article
Regression mapping of association between the human leukocyte antigen region and Graves disease.
American journal of human genetics - 1 Jan 2005
Simmonds Matthew J, Howson Joanna M M, Heward Joanne M, Cordell Heather J, Foxall Helen, Carr-Smith Jackie, Gibson Sarah M, Walker Neil, Tomer Yaron, Franklyn Jayne A, Todd John A, Gough Stephen C L
Abstract excerpt
The human leukocyte antigen class II genes DRB1, DQB1, and DQA1 are associated with Graves disease (GD), but, because of strong linkage disequilibrium within this region, the primary etiological variant(s) remains unknown. In the present study, 871 patients with GD and 621 control subjects were genotyped at the DRB1, DQB1, and DQA1 loci. All three loci were associated with GD (P=1.45 x 10(-12), P=3.20 x 10(-5),...
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