Article
Association of the HLA-DRB1*0301 and HLA-DQA1*0501 alleles with Graves' disease in a population representing the gene contribution from several ethnic backgrounds.
Thyroid : official journal of the American Thyroid Association - 1 Jan 2001
Maciel L M, Rodrigues S S, Dibbern R S, Navarro P A, Donadi E A
Abstract excerpt
Graves' disease (GD) is the most frequent cause of hyperthyroidism. Although the etiology is not completely elucidated, there are several lines of evidence suggesting multifactorial mechanisms. Genetic, constitutional, and environmental factors are involved in its pathogenesis. Major histocompatibility complex (MHC) class II alleles have been associated with GD in several populations of distinct ethnic...
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