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Article

Arginine at position 74 of the HLA-DR beta1 chain is associated with Graves' disease.

Genes and immunity - 1 May 2004

Ban Y, Davies T F, Greenberg D A, Concepcion E S, Osman R, Oashi T, Tomer Y

Abstract excerpt

Graves' disease (GD) is associated with HLA-DR3 (DRB1*03) in Caucasians, but the exact amino-acid sequence in the DR beta1 chain conferring susceptibility to GD is unknown. Therefore, the aim of our study was to identify the critical sequence among the HLA-DRB1 amino-acid residues occupying the peptide-binding pocket, which conferred susceptibility to GD. We sequenced the HLA-DRB1 locus in 208 Caucasian GD...

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Identifiers

PMID: 15029234
DOI: 10.1038/sj.gene.6364059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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