Article
Linkage disequilibrium between the human leukocyte antigen class II region of the major histocompatibility complex and Graves' disease: replication using a population case control and family-based study.
The Journal of clinical endocrinology and metabolism - 1 Oct 1998
Heward J M, Allahabadia A, Daykin J, Carr-Smith J, Daly A, Armitage M, Dodson P M, Sheppard M C, Barnett A H, Franklyn J A, Gough S C
Abstract excerpt
Early case control studies found association of the DRB1 allele, DR3, with Graves' disease (GD). Recent reports, claim the DQA1 allele, DQA1*0501, to be the primary susceptibility determinant within the human leukocyte antigen (HLA) class II region. We typed 228 GD patients, 364 controls, and 98...
Topics
- Alleles
- Case-Control Studies
- Fathers
- Female
- Genetic Linkage
- Graves Disease
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- HLA-DQ beta-Chains
- HLA-DR Antigens
- HLA-DRB1 Chains
- Haplotypes
- Histocompatibility Antigens Class II