Article
Linkage disequilibrium between the human leukocyte antigen class II region of the major histocompatibility complex and Graves' disease: replication using a population case control and family-based study.
The Journal of clinical endocrinology and metabolism - 1 Oct 1998
Heward J M, Allahabadia A, Daykin J, Carr-Smith J, Daly A, Armitage M, Dodson P M, Sheppard M C, Barnett A H, Franklyn J A, Gough S C
Abstract excerpt
Early case control studies found association of the DRB1 allele, DR3, with Graves' disease (GD). Recent reports, claim the DQA1 allele, DQA1*0501, to be the primary susceptibility determinant within the human leukocyte antigen (HLA) class II region. We typed 228 GD patients, 364 controls, and 98 families (parents, GD, and unaffected sibling) at the DRB1, DQB1, and DQA1 loci. The case control study showed an...
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