Article
Two HLA DRB 1 alleles confer independent genetic susceptibility to Graves disease: relevance of cross-population studies.
American journal of medical genetics - 1 Aug 2001
Marga M, Denisova A, Sochnev A, Pirags V, Farid N R
Abstract excerpt
Recent studies of Graves disease (GD) employing genome scanning techniques excluded the major histocompatibility complex as a contributor to disease liability. These findings contradict earlier population association studies. Our own earlier studies have also emphasized that genetic variation in human populations may give novel clues to disease liability and manifestations. To this end, we studied HLA class II...
Topics
- Adolescent
- Adult
- Aged
- Alleles
- DNA
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Graves Disease
- HLA-DR Antigens
- HLA-DRB1 Chains
- Humans
- Male
- Middle Aged
- Odds Ratio