Article
Identification of independent risk loci for Graves' disease within the MHC in the Japanese population.
Journal of human genetics - 1 Nov 2011
Nakabayashi Kazuhiko, Tajima Atsushi, Yamamoto Ken, Takahashi Atsushi, Hata Kenichiro, Takashima Yasuo, Koyanagi Midori, Nakaoka Hirofumi, Akamizu Takashi, Ishikawa Naofumi, Kubota Sumihisa, Maeda Shiro, Tsunoda Tatsuhiko, Kubo Michiaki, Kamatani Naoyuki, Nakamura Yusuke, Sasazuki Takehiko, Shirasawa Senji
Abstract excerpt
To identify genetic variants that confer the risk of Graves' disease (GD) in the Japanese population, we conducted a two-stage genome-wide association study (GWAS) using 1119 Japanese individuals with GD and 2718 unrelated controls, and a subsequent replication study using independent 432 GD cases and 1157 controls. We identified 34 single nucleotide polymorphisms (SNPs) to be significantly associated with GD in...
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