Phenotypical and functional alterations in the mucosal immune system of CD45 exon 9 KO mice.

doi:10.1093/intimm/dxh181

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Article

Phenotypical and functional alterations in the mucosal immune system of CD45 exon 9 KO mice.

International immunology - 1 Jan 2005

López María C, Holmes Nick

Abstract excerpt

The protein tyrosine phosphatase CD45 has been shown to be an important regulator of antigen-receptor signaling in both T and B lymphocytes. Lymphocyte populations within the gut mucosa are phenotypically and ontogenetically different from those generally found in secondary lymphoid tissue. In T lymphopenic mice, extrathymic T cell development takes place within the gut. Here we report the characterization of T...

Topics

Animals
Antigens, Surface
B-Lymphocytes
CD4-Positive T-Lymphocytes
Cell Differentiation
Cytokines
Exons
Female
Immune System
Intestinal Mucosa
Intestine, Large
Leukocyte Common Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Mutant Strains

Phenotype

Receptors, Antigen, T-Cell, alpha-beta

Receptors, Antigen, T-Cell, gamma-delta

Source

Open in PubMed

Identifiers

PMID: 15557316
DOI: 10.1093/intimm/dxh181

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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