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Article

Receptor editing in CD45-deficient immature B cells.

European journal of immunology - 1 Aug 2002

Shivtiel Shoham, Leider Nira, Melamed Doron

Abstract excerpt

B cell receptor signaling threshold regulates negative selection of autoreactive B cells and determines the mechanism of B cell tolerance. Using mice carrying immunoglobulin transgene specific for MHC class I antigen K(k) (3-83 Tg mice), and IL-7-driven bone marrow (BM) culture system, we have previously shown that receptor editing is a major mechanism in B cell tolerance. To test the role of BCR signaling...

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Source

Identifiers

PMID: 12209639
DOI: 10.1002/1521-4141(200208)32:8<2264::AID-IMMU2264>3.0.CO;2-E

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Receptor editing in CD45-deficient immature B cells.PMID 12209639Read ↗

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Receptor editing can lead to allelic inclusion and development of B cells that retain antibodies reacting with high avidity autoantigens.Semantic proximity Read ↗

Positive selection of natural poly-reactive B cells in the periphery occurs independent of heavy chain allelic inclusion.Semantic proximity Read ↗

Igkappa allelic inclusion is a consequence of receptor editing.Semantic proximity Read ↗

Impaired light chain allelic exclusion and lack of positive selection in immature B cells expressing incompetent receptor deficient of CD19.Semantic proximity Read ↗

B cell receptor editing in tolerance and autoimmunitySemantic proximity Read ↗

In Vivo Assessment of the Relative Contributions of Deletion, Anergy, and Editing to B Cell Self-ToleranceSemantic proximity Read ↗

Autoreactivity and allelic inclusion in a B cell nuclear transfer mouse.Semantic proximity Read ↗

An extracatalytic function of CD45 in B cells is mediated by CD22.Semantic proximity Read ↗

Receptor editing: an approach by autoreactive B cells to escape tolerance.Semantic proximity Read ↗

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