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Article

CD45 is required for type I IFN production by dendritic cells.

European journal of immunology - 1 Aug 2006

Montoya Maria, Dawes Ritu, Reid Delyth, Lee Lian Ni, Piercy Jenny, Borrow Persephone, Tchilian Elma Z, Beverley Peter C L

Abstract excerpt

CD45 is a leukocyte tyrosine phosphatase, essential for normal immune responses. We have studied the function of splenic dendritic cells of CD45(+/+), CD45(-/-), CD45RABC and CD45RO transgenic mice. We show that there are increased numbers of plasmacytoid dendritic cells in CD45(-/-) mice. DC of all mice are capable of responding to lymphocytic choriomeningitis virus (LCMV) infection by up-regulation of MHC and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16856204
DOI: 10.1002/eji.200535304

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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