Article
Thymus-independent development and negative selection of T cells expressing T cell receptor alpha/beta in the intestinal epithelium: evidence for distinct circulation patterns of gut- and thymus-derived T lymphocytes.
The Journal of experimental medicine - 1 Jul 1992
Poussier P, Edouard P, Lee C, Binnie M, Julius M
Abstract excerpt
We demonstrate that mouse intestinal intraepithelial lymphocytes (IEL) can be divided into subsets based on the differential expression of functional T cell receptor alpha/beta (TCR-alpha/beta) signaling complexes. Two subsets, CD4+ 8 alpha + beta - and CD8 alpha + beta -, are refractory to stimulation with anti-TCR-alpha/beta and contain high frequencies of potentially self-reactive cells. In contrast, the CD4+...
Topics
- Alleles
- Animals
- Antigens, Ly
- CD4 Antigens
- CD8 Antigens
- Epithelium
- Intestines
- Mice
- Mice, Inbred Strains
- Peyer's Patches
- Radiation Chimera