Article
Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine.
The EMBO journal - 1 Dec 1993
Liu C P, Ueda R, She J, Sancho J, Wang B, Weddell G, Loring J, Kurahara C, Dudley E C, Hayday A
Abstract excerpt
The T cell antigen receptor (TCR)-associated invariable membrane proteins (CD3-gamma, -delta, -epsilon and -zeta) are critical to the assembly and cell surface expression of the TCR/CD3 complex and to signal transduction upon engagement of TCR with antigen. Disruption of the CD3-zeta gene by homologous recombination resulted in a structurally abnormal thymus which primarily contained CD4- CD8- and TCR/CD3very...
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