Article
Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine.
The EMBO journal - 1 Dec 1993
Liu C P, Ueda R, She J, Sancho J, Wang B, Weddell G, Loring J, Kurahara C, Dudley E C, Hayday A
Abstract excerpt
The T cell antigen receptor (TCR)-associated invariable membrane proteins (CD3-gamma, -delta, -epsilon and -zeta) are critical to the assembly and cell surface expression of the TCR/CD3 complex and to signal transduction upon engagement of TCR with antigen. Disruption of the CD3-zeta gene by homo...
Topics
- Animals
- Blotting, Southern
- Blotting, Western
- CD3 Complex
- CD4 Antigens
- CD8 Antigens
- Cell Division
- Flow Cytometry
- Intestines
- Killer Cells, Natural
- Lymph Nodes
- Membrane Proteins
- Mice
- Mutation
- Receptors, Antigen, T-Cell