Constitutive biological activity of thymus-independent TCR-alpha-beta+ intestinal intraepithelial lymphocytes in TCR-alpha-/- gene disruption mice.

doi:10.1016/s0165-2478(96)02647-8

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Constitutive biological activity of thymus-independent TCR-alpha-beta+ intestinal intraepithelial lymphocytes in TCR-alpha-/- gene disruption mice.

Immunology letters - 1 Dec 1996

Neuhaus O, Emoto M, Kaufmann S H

Abstract excerpt

The surface of alpha beta T cells express a heterodimeric T cell receptor (TCR) composed of an alpha- and a beta-chain. In TCR-alpha gene disruption mutant mice, T cells can be identified which surface-express the TCR-beta chain in the absence of the TCR-alpha chain. Characteristically, intestinal intraepithelial lymphocytes (i-IELs) constitutively express biological functions which are demonstrable after TCR...

Topics

Animals
Gene Deletion
Intestinal Mucosa
Mice
Mice, Knockout
Mice, Transgenic
Phenotype
Receptors, Antigen, T-Cell, alpha-beta
T-Lymphocytes
Thymus Gland

Source

Open in PubMed

Identifiers

PMID: 9030982
DOI: 10.1016/s0165-2478(96)02647-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics