Article
Loss of αβ but not γδ T cells in chickens causes a severe phenotype.
European journal of immunology - 1 Dec 2023
von Heyl Theresa, Klinger Romina, Aumann Dorothea, Zenner Christian, Alhussien Mohanned, Schlickenrieder Antonina, Lengyel Kamila, Vikkula Hanna-Kaisa, Mittermair Teresa, Sid Hicham, Schusser Benjamin
Abstract excerpt
The availability of genetically modified mice has facilitated the study of mammalian T cells. No model has yet been developed to study these cells in chickens, an important livestock species with a high availability of γδ T cells. To investigate the role of γδ and αβ T cell populations in birds, we generated chickens lacking these T cell populations. This was achieved by genomic deletion of the constant region of...
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