Article
Altered glucose homeostasis in alpha2A-adrenoceptor knockout mice.
European journal of pharmacology - 28 Nov 2004
Fagerholm Veronica, Grönroos Tove, Marjamäki Päivi, Viljanen Tapio, Scheinin Mika, Haaparanta Merja
Abstract excerpt
To elucidate the functions of alpha2-adrenoceptor subtypes in metabolic regulation, we determined plasma glucose and insulin levels and tissue uptake of the glucose analogue 2-[18F]fluoro-2-deoxy-d-glucose ([18F]FDG) in C57Bl/6J wild-type (WT) and alpha2A-adrenoceptor knockout (alpha2A-KO) mice at baseline and following alpha2-adrenoceptor agonist ((+)-4-(S)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole...
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