Article
The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity.
The Journal of clinical investigation - 1 Jan 2003
Viollet Benoit, Andreelli Fabrizio, Jørgensen Sebastian B, Perrin Christophe, Geloen Alain, Flamez Daisy, Mu James, Lenzner Claudia, Baud Olivier, Bennoun Myriam, Gomas Emmanuel, Nicolas Gaël, Wojtaszewski Jørgen F P, Kahn Axel, Carling David, Schuit Frans C, Birnbaum Morris J, Richter Erik A, Burcelin Rémy, Vaulont Sophie
Abstract excerpt
AMP-activated protein kinase (AMPK) is viewed as a fuel sensor for glucose and lipid metabolism. To better understand the physiological role of AMPK, we generated a knockout mouse model in which the AMPKalpha2 catalytic subunit gene was inactivated. AMPKalpha2(-/-) mice presented high glucose levels in the fed period and during an oral glucose challenge associated with low insulin plasma levels. However, in...
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