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Article

The alpha2 isoform of Na,K-ATPase mediates ouabain-induced cardiac inotropy in mice.

The Journal of biological chemistry - 26 Dec 2003

Dostanic Iva, Lorenz John N, Schultz Jo El J, Grupp Ingrid L, Neumann Jonathan C, Wani Maqsood A, Lingrel Jerry B

Abstract excerpt

Inhibition of Na,K-ATPase activity by cardiac glycosides is believed to be the major mechanism by which this class of drugs increases heart contractility. However, direct evidence demonstrating this is lacking. Furthermore it is unknown which specific alpha isoform of Na,K-ATPase is responsible for the effect of cardiac glycosides. Several studies also suggest that cardiac glycosides, such as ouabain, function by...

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Identifiers

PMID: 14559919
DOI: 10.1074/jbc.M308547200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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