Variation in the α(2A) adrenoceptor gene and the effect of dexmedetomidine on plasma insulin and glucose.

doi:10.1097/FPC.0b013e3283642f93

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Article

Variation in the α(2A) adrenoceptor gene and the effect of dexmedetomidine on plasma insulin and glucose.

Pharmacogenetics and genomics - 1 Sept 2013

Ghimire Laxmi V, Muszkat Mordechai, Sofowora Gbenga G, Scheinin Mika, Wood Alastair J J, Stein C Michael, Kurnik Daniel

Abstract excerpt

OBJECTIVES: Sympathetic activation inhibits insulin secretion through activation of pancreatic α(2)A adrenoreceptors (α(2A)ARs). A common genetic α(2A)AR variant (rs553668) is associated with impaired insulin secretion. α(2A)R agonists would be expected to decrease insulin secretion, but their effects on glucose homeostasis in humans are poorly characterized. We examined the hypotheses that the selective α(2A)R...

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PMID: 23873118
DOI: 10.1097/FPC.0b013e3283642f93
PMCID: PMC3787837

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.