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Article

Impaired Hepatic Glucose Metabolism Is Associated With Glucose Intolerance in Mice Carrying α2 Isoform Na,K-ATPase Mutation.

Acta physiologica (Oxford, England) - 1 Oct 2026

Staehr Christian, Nguyen Tue Duy, Pedersen Tina Myhre, Vendelbo Mikkel, Beck Hans Christian, Kjolby Mads, Rajanathan Rajkumar, Bouzinova Elena V, Jessen Niels, Jeppesen Per Bendix, Chibalin Alexander V, Matchkov Vladimir V

Abstract excerpt

AIM: The Na,K-ATPase is important for energy demanding cellular processes, including essential components of substrate metabolism and metabolic flexibility. Mice heterozygous for the hemiplegic migraine-related mutation, G301R, of the Na,K-ATPase α2 isoform (α2 +/G301R) demonstrated altered metabolism in the heart. We hypothesized that mitochondrial dysfunction in α2 +/G301R mice is associated with abnormal...

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Topics

Animals
Male
Sodium-Potassium-Exchanging ATPase
Female
Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Glucose

Liver

Glucose Intolerance

Mutation

Source

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Identifiers

PMID: 42717423
DOI: 10.1111/apha.70291
PMCID: PMC13558787

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