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Article

The alpha2-isoform of Na-K-ATPase mediates ouabain-induced hypertension in mice and increased vascular contractility in vitro.

American journal of physiology. Heart and circulatory physiology - 1 Feb 2005

Dostanic Iva, Paul Richard J, Lorenz John N, Theriault Steven, Van Huysse James W, Lingrel Jerry B

Abstract excerpt

Although ouabain is known to induce hypertension, the mechanism of how this cardiac glycoside affects blood pressure is uncertain. The present study demonstrates that the alpha2-isoform of the Na-K-ATPase mediates the pressor effects of ouabain in mice. To accomplish this, we analyzed the effect of ouabain on blood pressure in wild-type mice, where the alpha2-isoform is sensitive to ouabain, and genetically...

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Identifiers

PMID: 15458945
DOI: 10.1152/ajpheart.00083.2004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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