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Article

Links between insulin resistance, adenosine A2B receptors, and inflammatory markers in mice and humans.

Diabetes - 1 Feb 2011

Figler Robert A, Wang Guoquan, Srinivasan Susseela, Jung Dae Young, Zhang Zhiyou, Pankow James S, Ravid Katya, Fredholm Bertil, Hedrick Catherine C, Rich Stephen S, Kim Jason K, LaNoue Kathryn F, Linden Joel

Abstract excerpt

OBJECTIVE: To determine the mechanisms by which blockade of adenosine A(2B) receptors (A(2B)Rs) reduces insulin resistance. RESEARCH DESIGN AND METHODS: We investigated the effects of deleting or blocking the A(2B)R on insulin sensitivity using glucose tolerance tests (GTTs) and hyperinsulinemic-euglycemic clamps in mouse models of type 2 diabetes. The effects of diabetes on A(2B)R transcription and signaling...

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Identifiers

PMID: 21270276
DOI: 10.2337/db10-1070
PMCID: PMC3028369

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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