Article
Hepatic muscarinic acetylcholine receptors are not critically involved in maintaining glucose homeostasis in mice.
Diabetes - 1 Dec 2009
Li Jian H, Gautam Dinesh, Han Sung-Jun, Guettier Jean-Marc, Cui Yinghong, Lu Huiyan, Deng Chuxia, O'Hare James, Jou William, Gavrilova Oksana, Buettner Christoph, Wess Jürgen
Abstract excerpt
OBJECTIVE: An increase in the rate of hepatic glucose production is the major determinant of fasting hyperglycemia in type 2 diabetes. A better understanding of the signaling pathways and molecules that regulate hepatic glucose metabolism is therefore of great clinical importance. Recent studies suggest that an increase in vagal outflow to the liver leads to decreased hepatic glucose production and reduced blood...
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