Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Central Hypotensive Effects of the α <sub>2a</sub> -Adrenergic Receptor Subtype

9 Aug 1996

Abstract excerpt

alpha2-Adrenergic receptors (alpha2ARs) present in the brainstem decrease blood pressure and are targets for clinically effective antihypertensive drugs. The existence of three alpha2AR subtypes, the lack of subtype-specific ligands, and the cross-reactivity of alpha2AR agonists with imidazoline receptors has precluded an understanding of the role of individual alpha2AR subtypes in the hypotensive response. Gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Neuroscience and Neuropharmacology Research
Share to Receptor Mechanisms and Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8670421
DOI: 10.1126/science.273.5276.801

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Central Hypotensive Effects of the α <sub>2a</sub> -Adrenergic Receptor SubtypePMID 8670421Read ↗

Substitution of a mutant alpha2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo.Semantic proximity Read ↗

Alpha 2-adrenergic receptor subtypes: subtle mutation of the alpha 2A-adrenergic receptor in vivo by gene targeting strategies reveals the role of this subtype in multiple physiological settings.Semantic proximity Read ↗

?2-Adrenergic Receptor Subtypes ? Novel Functions Uncovered in Gene-Targeted Mouse ModelsSemantic proximity Read ↗

An asn to lys polymorphism in the third intracellular loop of the human alpha 2A-adrenergic receptor imparts enhanced agonist-promoted Gi coupling.Semantic proximity Read ↗

Role of the alpha2B-adrenergic receptor in the development of salt-induced hypertension.Semantic proximity Read ↗

Role of alpha(2)-adrenergic receptor subtypes in the acute hypertensive response to hypertonic saline infusion in anephric mice.Semantic proximity Read ↗

Contribution of alpha(2) receptor subtypes to nerve injury-induced pain and its regulation by dexmedetomidine.Semantic proximity Read ↗

The alpha2-isoform of Na-K-ATPase mediates ouabain-induced hypertension in mice and increased vascular contractility in vitro.Semantic proximity Read ↗

Genetic variations of α(2)-adrenergic receptors illuminate the diversity of receptor functions.Semantic proximity Read ↗

Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2.Semantic proximity Read ↗

Hypotension, autonomic failure, and cardiac hypertrophy in transgenic mice overexpressing the alpha 1B-adrenergic receptor.Semantic proximity Read ↗

Genetic variation at the human alpha2B-adrenergic receptor locus: role in blood pressure variation and yohimbine response.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.