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Article

Age-related impairment in insulin release: the essential role of β(2)-adrenergic receptor.

Diabetes - 1 Mar 2012

Santulli Gaetano, Lombardi Angela, Sorriento Daniela, Anastasio Antonio, Del Giudice Carmine, Formisano Pietro, Béguinot Francesco, Trimarco Bruno, Miele Claudia, Iaccarino Guido

Abstract excerpt

In this study, we investigated the significance of β(2)-adrenergic receptor (β(2)AR) in age-related impaired insulin secretion and glucose homeostasis. We characterized the metabolic phenotype of β(2)AR-null C57Bl/6N mice (β(2)AR(-/-)) by performing in vivo and ex vivo experiments. In vitro assays in cultured INS-1E β-cells were carried out in order to clarify the mechanism by which β(2)AR deficiency affects...

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Identifiers

PMID: 22315324
DOI: 10.2337/db11-1027
PMCID: PMC3282797

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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