Article
CtBP family proteins: more than transcriptional corepressors.
BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Jan 2003
Chinnadurai G
Abstract excerpt
CtBP family proteins predominantly function as transcriptional corepressors. Studies with mutant mouse suggest that the two mouse genes, Ctbp1 and Ctbp2, play unique and redundant gene regulatory roles during development.1 Ctbp1-deficient mice are viable, but are small and die early, while Ctbp2 deficiency leads to embryonic lethality. Ctbp2-null mutation causes defects in axial patterning, heart morphogenesis...
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