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Article

Cbfbeta interacts with Runx2 and has a critical role in bone development.

Nature genetics - 1 Dec 2002

Kundu Mondira, Javed Amjad, Jeon Jae-Pil, Horner Alan, Shum Lillian, Eckhaus Michael, Muenke Maximilian, Lian Jane B, Yang Yingzi, Nuckolls Glen H, Stein Gary S, Liu P Paul

Abstract excerpt

Runx2 (runt-related transcription factor 2, also known as Cbfa1, Osf2 and AML3) is essential for bone development in mice, and mutations in RUNX2 are found in 65-80% of individuals with cleidocranial dysplasia. Although all Runx family members can interact with Cbfbeta (core-binding factor b, enc...

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Source

Identifiers

PMID: 12434156
DOI: 10.1038/ng1050

Genes

RUNX2
CBFB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12434156-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Cbfbeta interacts with Runx2 and has a critical role in bone development.PMID 12434156Read ↗

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Different Requirements of CBFB and RUNX2 in Skeletal Development among Calvaria, Limbs, Vertebrae and RibsSemantic proximity Read ↗

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