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Article

SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation.

Cell - 2 Jun 2006

Dobreva Gergana, Chahrour Maria, Dautzenberg Marcel, Chirivella Laura, Kanzler Benoit, Fariñas Isabel, Karsenty Gerard, Grosschedl Rudolf

Abstract excerpt

Vertebrate skeletogenesis involves two processes, skeletal patterning and osteoblast differentiation. Here, we show that Satb2, encoding a nuclear matrix protein, is expressed in branchial arches and in cells of the osteoblast lineage. Satb2-/- mice exhibit both craniofacial abnormalities that resemble those observed in humans carrying a translocation in SATB2 and defects in osteoblast differentiation and...

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Share to Activating Transcription Factor 4
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16751105
DOI: 10.1016/j.cell.2006.05.012

Genes

SATB2
ATF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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