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Article

The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development.

Development (Cambridge, England) - 1 May 1998

Tang S J, Hoodless P A, Lu Z, Breitman M L, McInnes R R, Wrana J L, Buchwald M

Abstract excerpt

TGFbeta-related factors are critical regulators of vertebrate mesoderm development. However, the signalling cascades required for their function during this developmental process are poorly defined. Tlx-2 is a homeobox gene expressed in the primitive streak of mouse embryos. Exogenous BMP-2 rapidly activates Tlx-2 expression in the epiblast of E6.5 embryos. A Tlx-2 promoter element responds to BMP-2 signals in...

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Share to Gene Expression Regulation, Developmental
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Knockout

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Share to Promoter Regions, Genetic

Share to Protein Serine-Threonine Kinases

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Source

Identifiers

PMID: 9550720
DOI: 10.1242/dev.125.10.1877

Genes

BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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