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Article

Core-binding factor beta interacts with Runx2 and is required for skeletal development.

Nature genetics - 1 Dec 2002

Yoshida Carolina A, Furuichi Tatsuya, Fujita Takashi, Fukuyama Ryo, Kanatani Naoko, Kobayashi Shinji, Satake Masanobu, Takada Kenji, Komori Toshihisa

Abstract excerpt

Core-binding factor beta (CBFbeta, also called polyomavirus enhancer binding protein 2beta (PEBP2B)) is associated with an inversion of chromosome 16 and is associated with acute myeloid leukemia in humans. CBFbeta forms a heterodimer with RUNX1 (runt-related transcription factor 1), which has a...

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Source

Identifiers

PMID: 12434152
DOI: 10.1038/ng1015

Genes

RUNX1
RUNX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12434152-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Core-binding factor beta interacts with Runx2 and is required for skeletal development.PMID 12434152Read ↗

Cbfbeta interacts with Runx2 and has a critical role in bone development.Semantic proximity Read ↗

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Cbfb Regulates Bone Development by Stabilizing Runx Family ProteinsSemantic proximity Read ↗

The core-binding factor beta subunit is required for bone formation and hematopoietic maturation.Semantic proximity Read ↗

Core binding factor and its role in normal hematopoietic developmentSemantic proximity Read ↗

Requisite roles of Runx2 and Cbfb in skeletal development.Semantic proximity Read ↗

Core binding factor beta (Cbfβ) controls the balance of chondrocyte proliferation and differentiation by upregulating Indian hedgehog (Ihh) expression and inhibiting parathyroid hormone-related protein receptor (PPR) expression in postnatal cartilage and bone formation.Semantic proximity Read ↗

Core binding factor beta (<i>CBFB</i>) haploinsufficiency due to an interstitial deletion at 16q21q22 resulting in delayed cranial ossification, cleft palate, congenital heart anomalies, and feeding difficulties but favorable outcomeSemantic proximity Read ↗

T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFbeta dosage.Semantic proximity Read ↗

Deletion of core-binding factor β (Cbfβ) in mesenchymal progenitor cells provides new insights into Cbfβ/Runxs complex function in cartilage and bone developmentSemantic proximity Read ↗

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