Article
Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53-independent pathway.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Dec 2005
Jerome-Majewska Loydie A, Jenkins Gerard P, Ernstoff Elana, Zindy Frederique, Sherr Charles J, Papaioannou Virginia E
Abstract excerpt
The closely related T-box genes Tbx2 and Tbx3 are both expressed in the developing mammary glands of mouse embryos and both have been implicated in mammary carcinogenesis. Tbx3 is essential for induction of the mammary placodes in mice. In humans, mutations in TBX3 are responsible for ulnar-mamma...
Topics
- Animals
- Crosses, Genetic
- DNA Primers
- Fluorescent Antibody Technique
- Genotype
- Histological Techniques
- In Situ Hybridization
- Mammary Glands, Animal
- Mice
- Mice, Inbred C57BL
- Mice, Inbred ICR
- Morphogenesis
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction