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Article

Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53-independent pathway.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Dec 2005

Jerome-Majewska Loydie A, Jenkins Gerard P, Ernstoff Elana, Zindy Frederique, Sherr Charles J, Papaioannou Virginia E

Abstract excerpt

The closely related T-box genes Tbx2 and Tbx3 are both expressed in the developing mammary glands of mouse embryos and both have been implicated in mammary carcinogenesis. Tbx3 is essential for induction of the mammary placodes in mice. In humans, mutations in TBX3 are responsible for ulnar-mammary syndrome. Here, we show a haploinsufficiency effect of Tbx3 on maintenance of the mammary placodes and on the extent...

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Source

Identifiers

PMID: 16222716
DOI: 10.1002/dvdy.20575

Genes

TBX3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53-independent pathway.PMID 16222716Read ↗

TBX3, the gene mutated in ulnar-mammary syndrome, promotes growth of mammary epithelial cells via repression of p19ARF, independently of p53.Semantic proximity Read ↗

Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome.Semantic proximity Read ↗

Tbx3 impinges on the p53 pathway to suppress apoptosis, facilitate cell transformation and block myogenic differentiation.Semantic proximity Read ↗

Mouse TBX3 mutants suggest novel molecular mechanisms for Ulnar-mammary syndrome.Semantic proximity Read ↗

A dominant repression domain in Tbx3 mediates transcriptional repression and cell immortalization: relevance to mutations in Tbx3 that cause ulnar-mammary syndrome.Semantic proximity Read ↗

Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome.Semantic proximity Read ↗

The ulnar-mammary syndrome gene, Tbx3, is a direct target of the retinoic acid signaling pathway, which regulates its expression during mouse limb development.Semantic proximity Read ↗

Diverse functional networks of Tbx3 in development and disease.Semantic proximity Read ↗

Novel TBX3 mutation data in families with ulnar-mammary syndrome indicate a genotype-phenotype relationship: mutations that do not disrupt the T-domain are associated with less severe limb defects.Semantic proximity Read ↗

The spectrum of mutations in TBX3: Genotype/Phenotype relationship in ulnar-mammary syndrome.Semantic proximity Read ↗

TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence.Semantic proximity Read ↗

Ulnar-mammary syndrome with dysmorphic facies and mental retardation caused by a novel 1.28 Mb deletion encompassing the TBX3 gene.Semantic proximity Read ↗

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