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Article

Activating transcription factor-2 affects skeletal growth by modulating pRb gene expression.

Mechanisms of development - 1 Jan 2000

Vale-Cruz Dustin S, Ma Qin, Syme Janet, LuValle Phyllis A

Abstract excerpt

Endochondral ossification is the process of skeletal bone growth via the formation of a cartilage template that subsequently undergoes mineralization to form trabecular bone. Genetic mutations affecting the proliferation or differentiation of chondrocytes result in skeletal abnormalities. Activating transcription factor-2 (ATF-2) modulates expression of cell cycle regulatory genes in chondrocytes, and mutation of...

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Identifiers

PMID: 18638549
DOI: 10.1016/j.mod.2008.06.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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