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Article

G protein-coupled receptor kinase 5 contains a DNA-binding nuclear localization sequence.

Molecular and cellular biology - 1 Dec 2004

Johnson Laura R, Scott Mark G H, Pitcher Julie A

Abstract excerpt

G protein-coupled receptor kinases (GRKs) mediate desensitization of agonist-occupied G protein-coupled receptors (GPCRs). Here we report that GRK5 contains a DNA-binding nuclear localization sequence (NLS) and that its nuclear localization is regulated by GPCR activation, results that suggest potential nuclear functions for GRK5. As assessed by fluorescence confocal microscopy, transfected and endogenous GRK5 is...

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Source

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Identifiers

PMID: 15542828
DOI: 10.1128/MCB.24.23.10169-10179.2004
PMCID: PMC529036

Genes

GRK5
GRK2
GRK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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