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Article

Nuclear transport of Kir/Gem requires specific signals and importin alpha5 and is regulated by calmodulin and predicted serine phosphorylations.

Traffic (Copenhagen, Denmark) - 1 Sept 2007

Mahalakshmi Ramasubbu N, Nagashima Kazuaki, Ng Mei Yong, Inagaki Nobuya, Hunziker Walter, Béguin Pascal

Abstract excerpt

Kir/Gem, together with Rad, Rem and Rem2, is a member of the RGK small GTP-binding protein family. These multifunctional proteins regulate voltage-gated calcium channel (VGCC) activity and cell-shape remodeling. Calmodulin and 14-3-3 binding modulate the functions of RGK proteins. Intriguingly, abolishing the binding of calmodulin or calmodulin and 14-3-3 results in nuclear accumulation of RGK proteins. Under...

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Identifiers

PMID: 17605761
DOI: 10.1111/j.1600-0854.2007.00598.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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