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Article

GPR158, an orphan member of G protein-coupled receptor Family C: glucocorticoid-stimulated expression and novel nuclear role.

PloS one - 1 Jan 2013

Patel Nitin, Itakura Tatsuo, Gonzalez Jose M, Schwartz Stephen G, Fini M Elizabeth

Abstract excerpt

Members of the large G protein-coupled receptor (GPCR) clan are implicated in many physiological and disease processes, making them important therapeutic drug targets. In the present study, we follow up on results of a pilot study suggesting a functional relationship between glucocorticoid (GC)-induced ocular hypertension and GPR158, one of three orphan members of the GPCR Family C. GC treatment increases levels...

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PMID: 23451275
DOI: 10.1371/journal.pone.0057843
PMCID: PMC3581496

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