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Article

Dynamic Trafficking of STAT5 Depends on an Unconventional Nuclear Localization Signal

1 Jan 2013

Abstract excerpt

Signal transducer and activator of transcription 5 (STAT5) is crucial for physiological processes that include hematopoiesis, liver metabolism and mammary gland development. However, aberrant continual activity of STAT5 has been causally linked to human leukemias and solid tumor formation. As a regulated transcription factor, precise cellular localization of STAT5 is essential. Conventional nuclear localization...

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PMID: 23704351
DOI: 10.1242/jcs.123042

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