Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.

Molecular & cellular proteomics : MCP - 1 Feb 2011

Greco Todd M, Yu Fang, Guise Amanda J, Cristea Ileana M

Abstract excerpt

Histone deacetylase 5 (HDAC5), a class IIa deacetylase, is a prominent regulator of cellular and epigenetic processes that underlie the progression of human disease, ranging from cardiac hypertrophy to cancer. Although it is established that phosphorylation mediates 14-3-3 protein binding and provides the essential link between HDAC5 nucleo-cytoplasmic shuttling and transcriptional repression, thus far only four...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 14-3-3 Proteins
Share to Active Transport, Cell Nucleus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatography, Liquid

Share to Cytoplasm

Share to Green Fluorescent Proteins

Share to Histone Deacetylases

Share to Nuclear Localization Signals

Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Source

Open in PubMed Open full text

Identifiers

PMID: 21081666
DOI: 10.1074/mcp.M110.004317
PMCID: PMC3033682

Genes

HDAC5
HDAC3
HDAC4
HDAC9

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.PMID 21081666Read ↗

β-Adrenergic Stimulation Induces Histone Deacetylase 5 (HDAC5) Nuclear Accumulation in Cardiomyocytes by B55α-PP2A-Mediated Dephosphorylation.Semantic proximity Read ↗

Identification and characterization of a novel phosphoregulatory site on cyclin-dependent kinase 5.Semantic proximity Read ↗

Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization.Semantic proximity Read ↗

HDAC6 Substrate Discovery Using Proteomics-Based Substrate Trapping: HDAC6 Deacetylates PRMT5 to Influence Methyltransferase Activity.Semantic proximity Read ↗

Pathogenic mutations of human phosphorylation sites affect protein-protein interactionsSemantic proximity Read ↗

Pathogenic mutations of human phosphorylation sites affect protein-protein interactions.Semantic proximity Read ↗

Histone deacetylase 1 phosphorylation promotes enzymatic activity and complex formation.Semantic proximity Read ↗

Mitotic phosphorylation of histone H3 threonine 80.Semantic proximity Read ↗

A phospho-regulated signal motif determines subcellular localization of α-TAT1 for dynamic microtubule acetylationSemantic proximity Read ↗

Nuclear CaMKII Isoforms as Regulators of Transcription: From Developmental to Pathological PersistenceSemantic proximity Read ↗

Unraveling Site-Specific and Combinatorial Histone Modifications Using High-Resolution Mass Spectrometry in Histone Deacetylase Mutants of Fission Yeast.Semantic proximity Read ↗

Evaluating splicing factor and kinase network crosstalk through global phosphoproteomicsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.