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Article

Nuclear localization drives α1-adrenergic receptor oligomerization and signaling in cardiac myocytes.

Cellular signalling - 1 Mar 2012

Wright Casey D, Wu Steven C, Dahl Erika F, Sazama Alan J, O'Connell Timothy D

Abstract excerpt

Conventional models of G-protein coupled receptor (GPCR) signaling describe cell surface receptors binding to external ligands, such as hormones or circulating peptides, to induce intracellular signaling and a physiologic response. However, recent studies identify new paradigms indicating that GPCRs localize to and signal at the nucleus and that GPCR oligomers can influence receptor function. Previously, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22120526
DOI: 10.1016/j.cellsig.2011.11.014
PMCID: PMC3393107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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