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Article

A predicted amphipathic helix mediates plasma membrane localization of GRK5.

The Journal of biological chemistry - 23 Apr 2004

Thiyagarajan Manimekalai M, Stracquatanio RoseAnn P, Pronin Alexey N, Evanko Daniel S, Benovic Jeffrey L, Wedegaertner Philip B

Abstract excerpt

G protein-coupled receptor kinases (GRKs) specifically phosphorylate agonist-occupied G protein-coupled receptors at the inner surface of the plasma membrane (PM), leading to receptor desensitization. GRKs utilize a variety of mechanisms to bind tightly, and sometimes reversibly, to cellular memb...

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Source

Identifiers

PMID: 14976207
DOI: 10.1074/jbc.M310738200

Genes

GRK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14976207-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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