Article
GRK5-mediated exacerbation of pathological cardiac hypertrophy involves facilitation of nuclear NFAT activity.
Circulation research - 5 Dec 2014
Hullmann Jonathan E, Grisanti Laurel A, Makarewich Catherine A, Gao Erhe, Gold Jessica I, Chuprun J Kurt, Tilley Douglas G, Houser Steven R, Koch Walter J
Abstract excerpt
RATIONALE: G protein-coupled receptor kinases (GRKs) acting in the cardiomyocyte regulate important signaling events that control cardiac function. Both GRK2 and GRK5, the predominant GRKs expressed in the heart, have been shown to be upregulated in failing human myocardium. Although the canonical role of GRKs is to desensitize G protein-coupled receptors via phosphorylation, it has been demonstrated that GRK5,...
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