Article

Unexpected functional role of the transactivation domain for nuclear import of STAT5

2025-12-14

Abstract excerpt

Signal transducer and activator of transcription 5 (STAT5) is a key transcriptional regulator acting downstream of hematopoietic cytokines and hormones, such as erythropoietin (Epo), thrombopoietin or prolactin. STAT5-mediated gene regulation involves tyrosine phosphorylation at cytokine receptors and subsequent nuclear import. We studied STAT5 nucleocytoplasmic shuttling via live-cell imaging of fluorescent mutan...

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Literature Corpus work: 3854f57b-0baf-556a-9fe4-db16e0faa6b4
DOI: 10.64898/2025.12.11.693681

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