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Article

Plasma membrane and nuclear localization of G protein coupled receptor kinase 6A.

Molecular biology of the cell - 1 Aug 2007

Jiang Xiaoshan, Benovic Jeffrey L, Wedegaertner Philip B

Abstract excerpt

G protein-coupled receptor (GPCR) kinases (GRKs) specifically phosphorylate agonist-occupied GPCRs at the inner surface of the plasma membrane (PM), leading to receptor desensitization. Here we show that the C-terminal 30 amino acids of GRK6A contain multiple elements that either promote or inhibit PM localization. Disruption of palmitoylation by individual mutation of cysteine 561, 562, or 565 or treatment of...

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Identifiers

PMID: 17538017
DOI: 10.1091/mbc.e07-01-0013
PMCID: PMC1949383

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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